Product Dose

Adults

10% to 20% continuous IV infusion at a rate of 25 to 75 mL/hour. Give IV loop diuretics prior to mannitol. Monitor cardiovascular status, urine output, serum electrolytes, and serum osmolarity during the infusion. In patients with symptomatic hyponatremia, 25 g IV bolus as a 20% solution every 1 hour as needed. Alternatively, 20% continuous IV infusion at a rate of 100 to 125 mL/hour.[31940] [31946] Other authors recommend 100 g IV as 10% to 20% solution over 2 to 6 hours. NOTE: Each 50 g of mannitol transfers 1,000 mL of water intracellularly to extracellularly.[31946]

Children† and Adolescents

Safety and efficacy have not been established; however, 0.5 to 2 g/kg IV of mannitol 15% to 20% over 2 to 6 hours has been used. Three children with nephrotic syndrome resistant to standard treatments, including diuretics, responded to daily administrations of 5 mL/kg IV of mannitol 20% over 1 hour. The patients also received a daily dose of furosemide 2 mg/kg.

Safety and efficacy have not been established; however, 0.5 to 2 g/kg IV of mannitol 15% to 20% over 2 to 6 hours has been used. Three children with nephrotic syndrome resistant to standard treatments, including diuretics, responded to daily administrations of 5 mL/kg IV of mannitol 20% over 1 hour. The patients also received a daily dose of furosemide 2 mg/kg.Adults

10% to 20% continuous IV infusion at a rate of 25 to 75 mL/hour. Give IV loop diuretics prior to mannitol. Monitor cardiovascular status, urine output, serum electrolytes, and serum osmolarity during the infusion. In patients with symptomatic hyponatremia, 25 g IV bolus as a 20% solution every 1 hour as needed. Alternatively, 20% continuous IV infusion at a rate of 100 to 125 mL/hour.[31940] [31946] Other authors recommend 100 g IV as 10% to 20% solution over 2 to 6 hours. NOTE: Each 50 g of mannitol transfers 1,000 mL of water intracellularly to extracellularly.[31946]

Children† and Adolescents†

Safety and efficacy have not been established; however, 0.5 to 2 g/kg IV of mannitol 15% to 20% over 2 to 6 hours has been used. Three children with nephrotic syndrome resistant to standard treatments, including diuretics, responded to daily administrations of 5 mL/kg IV of mannitol 20% over 1 hour. The patients also received a daily dose of furosemide 2 mg/kg.